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NAN-190 hydrobromide
CAS No. 115338-32-4
NAN-190 hydrobromide ( NAN190 hydrobromide | NAN 190 hydrobromide )
产品货号. M10539 CAS No. 115338-32-4
NAN-190 是一种 5-HT1A 受体拮抗剂，Ki 为 0.6 nM；还有效阻断 α2-肾上腺素能受体。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥259 | 有现货 |
|
| 10MG | ￥373 | 有现货 |
|
| 50MG | ￥599 | 有现货 |
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| 100MG | ￥778 | 有现货 |
|
| 200MG | ￥1401 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NAN-190 hydrobromide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NAN-190 是一种 5-HT1A 受体拮抗剂，Ki 为 0.6 nM；还有效阻断 α2-肾上腺素能受体。
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产品描述NAN-190 is a 5-HT1A receptor antagonist with Ki of 0.6 nM; also potently blocks the α2-adrenergic receptor; antagonizes the stimulation by norepinephrine of phosphoinositide turnover in rat cortical slices.Anxiety Preclinical
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体外实验——
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体内实验NAN-190 hydrobromide (0.5 mg/kg, ip) is injected concomitantly with the effective dose of fluoxetine. NAN-190 reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats.
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同义词NAN190 hydrobromide | NAN 190 hydrobromide
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域Neurological Disease
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适应症Anxiety
化学信息
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CAS Number115338-32-4
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分子量474.3907
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分子式C23H28BrN3O3
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纯度>98% (HPLC)
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溶解度DMSO: 36.23 mg/mL
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SMILESCOC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br
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化学全称1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrobromide (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Claustre Y, et al. Eur J Pharmacol. 1991 Oct 29;204(1):71-7.
2. Zhang J, et al. J Neurosci. 2010 Feb 17;30(7):2433-41.
3. Glennon RA, et al. J Med Chem. 1988 Oct;31(10):1968-71.
产品手册
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